Friedel-Crafts Acylation Tutorial

Tutorial and Self Assessment AvailableElectrophilic aromatic substitution

Friedel-Crafts acylation

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Friedel-Crafts acylation occurs with acid chlorides and the Lewis acid AlCl3. Acid chlorides can give the rather stable acylium ion even in hydrolytic reactions and they do so readily with Lewis acid catalysis. Attack on a benzene ring then gives an aromatic ketone. The benzene ring has been acylated.