Base-Catalysed Bromination of Ketones

Click each of the reaction schemes below to view the 3D models and animations respectively

Sn2

The hydroxide removes a proton from the ketone to form an enolate anion. The enolate anion attacks the bromine molecule yielding a mono-substituted bromoketone. The reaction continues until the tribromoketone is formed. The hydroxide then attacks directly at the carbonyl and a tribromomethyl anion is lost.

 

 

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