Conjugate Addition Reactions

A range of nucleophiles will undergo conjugate additions with α,β-unsaturated carbonyl compounds (or other electron acceptor groups such as nitrile). Some varied examples are shown below:

Conjugate addition mechanisms

Click each reaction to view the associated 3D animations

A. G. Csákÿ, G. de la Herrán and M. C. Murcia, Chem. Soc. Rev., 2010, 39, 4080.