Friedel-Crafts Alkylation Tutorial

Tutorial and Self Assessment AvailableElectrophilic aromatic substitution

Friedel-Crafts alkylation

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Click the structures and reaction arrows in sequence to view the 3D models and animations respectively

Friedel-Crafts alkylation usually involves treating benzene with a secondary or tertiary alkyl halide, and the Lewis acid AlCl3. In this example, the Lewis acid removes the chloride atom from the t-BuCl, which then releases the t-Bu cation for the alkylation reaction. Chloride then removes the proton from the cationic intermediate restoring aromaticity.

Other pages of interest to do with Animated Molecular Orbitals are

Introduction to Animated Molecular Orbitals | Introductory Organic Reactions

G. A. Olah, Acc. Chem. Res., 1971, 4, 240–248.

 

 

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