Hantzsch pyridine synthesis

 

The Hantzsch synthesis is a four-component reaction between an aldehyde, two equivalents of a β-ketoester and ammonia, followed by oxidation to give a pyridine-3,5-dicarboxylate. Subsequent decarboxylation gives the corresponding pyridines.

Sn2

'Click' the different stages to view the 3D models of the reaction:

Sn2

 

 

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