Aromatic heterocycles

Thiophene ring formation

Background Colour:


Click the structures and reaction arrows in sequence to view the 3D models and animations respectively

The unstable 1,4-dithioketone can eliminate hydrogen sulfide and form the stable aromatic heterocycle thiophene by cyclization.

T. Ozturk, E. Ertas and O. Mert, Chem. Rev., 2007, 107, 5210–5278.