Carbonyl Addition - Loss of carbonyl oxygen

Enamine formation

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Under the appropriate conditions, secondary amines react with carbonyl compounds to form enamines. Like imine formation, the formation of an enamine also requires an acid catalyst for the removal of water.

G. Stork, A. Brizzolara, H. Landesman, J. Szmuszkovicz and R. Terrell, J. Am. Chem. Soc., 1963, 85, 207–222.

 

 

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