Pyridine Nucleophilic Substitution Tutorial

Tutorial and Self Assessment Available Pyridine

Nucleophilic Substitution

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NOTE: Important charges and non-bonding electrons are shown throughout the animation except during the transition phase

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Nucleophilic substitution takes place preferentially at the 2- and 4- positions as the intermediate anion is stabilised by the electronegative nitrogen.

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B. Hamper and E. Tesfu, Synlett, 2007, 2007, 2257–2261.