NOTE: Important charges and non-bonding electrons are shown throughout the animation except during the transition phase

^{Click the structures and reaction arrows to view the 3D models and animations respectively}

Nucleophilic substitution reactions take place at positions ortho- and para- to the N-oxide. Incorporation of the chlorine atom is useful as further nucleophilic substitution reactions can take place at this position.

Back to Aromatic Heterocycles