Pyrrole

The Mannich Reaction

 

 

The Mannich reaction is an electrophilic substitution reaction. The use of strong acids must be avoided. The reaction can be broken down into two stages: formation of an iminium ion and electrophilic substitution. CLICK the stages below (for the major product) to view each 3D animation respectively.

 

 

Back to Aromatic Heterocycles

M. Arend, B. Westermann and N. Risch, Angew. Chemie Int. Ed., 1998, 37, 1044–1070.

 

 

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